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Prediagnosis social support, social integration, living status, and colorectal cancer mortality in postmenopausal women from the women's health initiative
Background We evaluated associations between perceived social support, social integration, living alone, and colorectal cancer (CRC) outcomes in postmenopausal women. Methods The study included 1431 women from the Women's Health Initiative who were diagnosed from 1993 through 2017 with stage I...
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Published in: | Cancer 2020-04, Vol.126 (8), p.1766-1775 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
We evaluated associations between perceived social support, social integration, living alone, and colorectal cancer (CRC) outcomes in postmenopausal women.
Methods
The study included 1431 women from the Women's Health Initiative who were diagnosed from 1993 through 2017 with stage I through IV CRC and who responded to the Medical Outcomes Study Social Support survey before their CRC diagnosis. We used proportional hazards regression to evaluate associations of social support (tertiles) and types of support, assessed up to 6 years before diagnosis, with overall and CRC‐specific mortality. We also assessed associations of social integration and living alone with outcomes also in a subset of 1141 women who had information available on social ties (marital/partner status, community and religious participation) and living situation.
Results
In multivariable analyses, women with low (hazard ratio [HR], 1.52; 95% CI, 1.23‐1.88) and moderate (HR, 1.21; 95% CI, 0.98‐1.50) perceived social support had significantly higher overall mortality than those with high support (P [continuous] |
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ISSN: | 0008-543X 1097-0142 |
DOI: | 10.1002/cncr.32710 |