E‐cadherin deregulation in breast cancer

E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe th...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-06, Vol.24 (11), p.5930-5936
Main Authors: Corso, Giovanni, Figueiredo, Joana, De Angelis, Simone Pietro, Corso, Federica, Girardi, Antonia, Pereira, Joana, Seruca, Raquel, Bonanni, Bernardo, Carneiro, Patricia, Pravettoni, Gabriella, Guerini Rocco, Elena, Veronesi, Paolo, Montagna, Giacomo, Sacchini, Virgilio, Gandini, Sara
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor - genetics
Breast cancer
breast cancer metastases
breast cancer prognosis
breast cancer survival
Breast Neoplasms - genetics
Cadherins - genetics
Cadherins - metabolism
CDH1 gene
Cell adhesion & migration
E-cadherin
Epigenetics
Female
Gene expression
Gene Expression Regulation, Neoplastic
Humans
Lymphatic system
Medical prognosis
Metastases
Metastasis
Molecular Targeted Therapy
Mutation
Prognosis
Proteins
Review
Reviews
Studies
Tumors
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Description
Summary:E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.15140