Extensive hard palate hyperpigmentation associated with chloroquine use

A 66‐year‐old woman diagnosed clinical manifestation of extensive hard palate hyperpigmentation is presented. Due to historic of rheumatoid arthritis and use of chloroquine phosphate for 3 years, exogenous hyperpigmentation associated with the drug was included among the possible diagnoses. Incision...

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Bibliographic Details
Published in:British Journal of Clinical Pharmacology 2020-11, Vol.86 (11), p.2325-2327
Main Authors: Godinho, Géssica Vasconcelos, Paz, Ana Luiza Lima Medeiros, Araújo Gomes, Elâine Patrícia Alves, Garcia, Cristiane Loreda, Volpato, Luiz Evaristo Ricci
Format: Article
Language:English
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Letter to the Editor
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Summary:A 66‐year‐old woman diagnosed clinical manifestation of extensive hard palate hyperpigmentation is presented. Due to historic of rheumatoid arthritis and use of chloroquine phosphate for 3 years, exogenous hyperpigmentation associated with the drug was included among the possible diagnoses. Incisional biopsy was performed and the histopathological exam confirmed exogenous hyperpigmentation compatible with chloroquine use. The patient was referred to the rheumatologist and the ophthalmologist for evaluation of the continuity of the chloroquine use. After one year of follow‐up, no changes were seen in the hyperpigmentation nor other clinical changes. Hyperpigmentation of the hard palate by the use of chloroquine is one of the adverse effects of the chronic use of this drug and does not require specific treatment. The adequate anamnesis and the knowledge about the adverse effects of the drug allowed an adequate therapeutic approach in the case.
ISSN:0306-5251
1365-2125
DOI:10.1111/bcp.14313