Selective modification of fluciclovine (18F) transport in prostate carcinoma xenografts

We investigated if previously demonstrated inhibition of fluciclovine ( 18 F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovin...

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Bibliographic Details
Published in:Amino acids 2018-09, Vol.50 (9), p.1301-1305
Main Authors: Tade, F. I., Wiles, W. G., Lu, G., Bilir, B., Akin-Akintayo, O., Lee, J. S., Patil, D., Yu, W., Ormenisan Gherasim, C., Fei, B., Moreno, C. S., Osunkoya, A. O., Teoh, E. J., Oka, S., Okudaira, H., Goodman, M. M., Schuster, D. M.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animals
Biochemical Engineering
Biochemistry
Biological Transport
Biomedical and Life Sciences
Carboxylic Acids - chemistry
Carboxylic Acids - metabolism
Cell Line, Tumor
Cyclobutanes - chemistry
Cyclobutanes - metabolism
Heptanes
Heterografts
Humans
Isobutyric acid
Life Sciences
Luminescence
Male
Mice
Mice, Nude
Neurobiology
Positron Emission Tomography Computed Tomography
Prostate
Prostate - chemistry
Prostate - metabolism
Prostate cancer
Prostate carcinoma
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - metabolism
Proteomics
Short Communication
Xenografts
Xenotransplantation
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Summary:We investigated if previously demonstrated inhibition of fluciclovine ( 18 F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (± 5.4)% and 25.3 (± 5.2)% lower in BCH ( n  = 6) and MeAIB ( n  = 5) injected PC3 Luc xenografts, respectively, compared to saline-injected controls ( n  = 2). Partial inhibition of fluciclovine uptake by BCH and MeAIB can be demonstrated in vivo similar to previous in vitro modeling.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-018-2600-0