Disease Phenotyping of Infants with Severe Bronchopulmonary Dysplasia

Mandell et al. discuss the disease phenotype in infants with severe bronchopulmonary dysplasia (BPD). The paper by Wu et al. present exciting new work that helps define the frequency of three critical disease components in BPD. Nearly three-quarters of infants were diagnosed with at least two or mor...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2020-06, Vol.201 (11), p.1327-1329
Main Authors: Mandell, Erica, Hysinger, Erik B, McGrath-Morrow, Sharon A
Format: Article
Language:English
Subjects:
Babies
Bronchopulmonary Dysplasia
Genotype & phenotype
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
Infant, Very Low Birth Weight
Medical diagnosis
Phenotype
Respiratory diseases
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Summary:Mandell et al. discuss the disease phenotype in infants with severe bronchopulmonary dysplasia (BPD). The paper by Wu et al. present exciting new work that helps define the frequency of three critical disease components in BPD. Nearly three-quarters of infants were diagnosed with at least two or more disease components, suggesting that the presence of a single, predominant pathophysiology in infants with severe BPD may be true for only a minority of patients. Of the 73 infants classified, 78% had moderate-to-severe parenchymal lung disease, 66% had PH, and 60% had large airway disease. Presence of all three disease components was the most common phenotype observed in 32% of infants with severe BPD.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.202002-0305ED