Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial

To examine the effects of 30% oral dextrose on biochemical markers of pain, adenosine triphosphate (ATP) degradation, and oxidative stress in preterm neonates experiencing a clinically required heel lance. Utilizing a prospective study design, preterm neonates that met study criteria (n = 169) were...

Full description

Saved in:
Bibliographic Details
Published in:Journal of perinatology 2020-06, Vol.40 (6), p.888-895
Main Authors: Angeles, Danilyn M, Boskovic, Danilo S, Tan, John C, Shih, Wendy, Hoch, Erin, Forde, Dorothy, Phillips, Raylene M, Hopper, Andrew, Deming, Douglas D, Goldstein, Mitchell, Truong, Giang, Febre, Aprille, Pegis, Priscilla, Lavery, Adrian, Kadri, Munaf, Banerji, Anamika, Mousselli, Iman, Farha, Vora, Fayard, Elba
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Allantoin
ATP
Biochemical markers
Care and treatment
Degradation
Dextrose
Ethylenediaminetetraacetic acid
Glucose
Hypoxanthine
Infants (Premature)
Instrument industry
Markers
Metabolism
Muscle proteins
Neonates
Newborn babies
Oxidative stress
Pain
Uric acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To examine the effects of 30% oral dextrose on biochemical markers of pain, adenosine triphosphate (ATP) degradation, and oxidative stress in preterm neonates experiencing a clinically required heel lance. Utilizing a prospective study design, preterm neonates that met study criteria (n = 169) were randomized to receive either (1) 30% oral dextrose, (2) facilitated tucking, or (3) 30% oral dextrose and facilitated tucking 2 min before heel lance. Plasma markers of ATP degradation (hypoxanthine, uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured using the premature infant pain profile-revised (PIPP-R). Oral dextrose, administered alone or with facilitated tucking, did not alter plasma markers of ATP utilization and oxidative stress. A single dose of 30% oral dextrose, given before a clinically required heel lance, decreased signs of pain without increasing ATP utilization and oxidative stress in premature neonates.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-020-0634-0