Effect of 5-year continuous positive airway pressure treatment on MMPs and TIMPs: implications for OSA comorbidities

Continuous positive airway pressure (CPAP) treatment results in nearly complete remission of symptoms of obstructive sleep apnoea (OSA); however, its effect on OSA comorbidities including cardiovascular diseases remains contradictory. Here we investigated the short- and long-term effect of CPAP trea...

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Bibliographic Details
Published in:Scientific reports 2020-05, Vol.10 (1), p.8609-8609, Article 8609
Main Authors: Simon, Beatrix, Barta, Imre, Gabor, Bettina, Paska, Csilla, Boszormenyi Nagy, Gyorgy, Vizi, Eva, Antus, Balazs
Format: Article
Language:English
Subjects:
Apnea
Cardiovascular diseases
Continuous positive airway pressure
Gelatinase B
Matrix metalloproteinase
Neutrophil collagenase
Pressure
Remission
Respiratory tract
Serum levels
Sleep
Sleep apnea
Sleep disorders
Tissue inhibitor of metalloproteinases
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Summary:Continuous positive airway pressure (CPAP) treatment results in nearly complete remission of symptoms of obstructive sleep apnoea (OSA); however, its effect on OSA comorbidities including cardiovascular diseases remains contradictory. Here we investigated the short- and long-term effect of CPAP treatment on matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in patients with severe OSA. Serum levels of 7 MMPs and 3 TIMPs were followed in OSA patients (n = 28) with an apnoea-hypopnoea index of ≥30 events/h at the time of diagnosis and at control visits (2 months, 6 months and 5 years) after initiation of fixed-pressure CPAP treatment. The first few months of CPAP therapy resulted in significant decrease of MMP-8 and MMP-9 levels (MMP-8: 146 (79-237) vs. 287 (170-560) pg/mL; MMP-9: 10.1 (7.1-14.1) vs. 12.7 (10.4-15.6) ng/mL, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-65029-6