Prevention of Pain During Screening for Retinopathy of Prematurity: A Randomized Control Trial Comparing Breast Milk, 10% Dextrose and Sterile Water

Objectives To compare the efficacy of orally administered 10% dextrose, breast milk and sterile water on pain prevention during screening examination for Retinopathy of prematurity (ROP) in preterm neonates as measured by Premature infant pain profile (PIPP). Methods A three-limbed double-blinded ra...

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Bibliographic Details
Published in:Indian journal of pediatrics 2020-05, Vol.87 (5), p.353-358
Main Authors: Nayak, Ramya, Nagaraj, Kalale Nikhil, Gururaj, Girish
Format: Article
Language:English
Subjects:
Animals
Double-Blind Method
Female
Glucose
Gynecology
Humans
Infant
Infant, Newborn
Medicine
Medicine & Public Health
Milk, Human
Original
Original Article
Pain - diagnosis
Pain - etiology
Pain - prevention & control
Pediatrics
Retinopathy of Prematurity - diagnosis
Retinopathy of Prematurity - prevention & control
Water
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Summary:Objectives To compare the efficacy of orally administered 10% dextrose, breast milk and sterile water on pain prevention during screening examination for Retinopathy of prematurity (ROP) in preterm neonates as measured by Premature infant pain profile (PIPP). Methods A three-limbed double-blinded randomized control trial was conducted in a Level 3 neonatal intensive care unit. Forty five preterm neonates undergoing ROP screening were included. Eligible babies were randomly assigned to one of the three groups that orally received either expressed breast milk ( n  = 14), 10% dextrose solution (n = 14) or sterile water ( n  = 17), one minute before eye examination. The outcome measure was PIPP score. Results All 3 groups were similar in baseline characteristics. The mean PIPP scores were comparable ( p  = 0.18) in the three groups (11.8 ± 2.8 vs . 9.8 ± 3.3 vs. 10.2 ± 2.9). The behavioral and physiological variables were also similar across all three groups. Conclusions Expressed breast milk, 10% dextrose or sterile water administered orally before ROP screening in preterm neonates have similar analgesic effects and do not significantly alleviate pain during the procedure.
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-020-03182-6