Structure and function of the co-chaperone protein phosphatase 5 in cancer

Protein phosphatase 5 (PP5) is a serine/threonine protein phosphatase that regulates many cellular functions including steroid hormone signaling, stress response, proliferation, apoptosis, and DNA repair. PP5 is also a co-chaperone of the heat shock protein 90 molecular chaperone machinery that assi...

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Bibliographic Details
Published in:	Cell stress & chaperones 2020-05, Vol.25 (3), p.383-394
Main Authors:	Sager, Rebecca A., Dushukyan, Natela, Woodford, Mark, Mollapour, Mehdi
Format:	Article
Language:	eng
Subjects:	Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Breast Neoplasms - enzymology Cancer Cancer Research Catalytic Domain Cell Biology Cell survival Cellular stress response DNA repair Female Heat shock proteins HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Humans Immunology Kidney cancer MINI REVIEW Neoplasms - drug therapy Neoplasms - enzymology Neurosciences Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - chemistry Nuclear Proteins - metabolism Nuclear Proteins - physiology Phosphatase Phosphoprotein phosphatase Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - chemistry Phosphoprotein Phosphatases - metabolism Phosphoprotein Phosphatases - physiology Protein phosphatase Proteins Serine Signaling Steroids Structure-function relationships Survival Therapeutic applications Threonine
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Summary:	Protein phosphatase 5 (PP5) is a serine/threonine protein phosphatase that regulates many cellular functions including steroid hormone signaling, stress response, proliferation, apoptosis, and DNA repair. PP5 is also a co-chaperone of the heat shock protein 90 molecular chaperone machinery that assists in regulation of cellular signaling pathways essential for cell survival and growth. PP5 plays a significant role in survival and propagation of multiple cancers, which makes it a promising target for cancer therapy. Though there are several naturally occurring PP5 inhibitors, none is specific for PP5. Here, we review the roles of PP5 in cancer progression and survival and discuss the unique features of the PP5 structure that differentiate it from other phosphoprotein phosphatase (PPP) family members and make it an attractive therapeutic target.
ISSN:	1355-8145 1466-1268