The role of innate immunity in the long-term outcome of lung transplantation

Long-term survival after lung transplantation remains suboptimal due to chronic lung allograft dysfunction (CLAD), a progressive scarring process affecting the graft. Although anti-donor alloimmunity is central to the pathogenesis of CLAD, its underlying mechanisms are not fully elucidated and it is...

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Bibliographic Details
Published in:Annals of translational medicine 2020-03, Vol.8 (6), p.412-412
Main Authors: Kawashima, Mitsuaki, Juvet, Stephen C
Format: Article
Language:English
Subjects:
Review on Strategies to Achieve Long-Term Success of Lung Transplantation
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Summary:Long-term survival after lung transplantation remains suboptimal due to chronic lung allograft dysfunction (CLAD), a progressive scarring process affecting the graft. Although anti-donor alloimmunity is central to the pathogenesis of CLAD, its underlying mechanisms are not fully elucidated and it is neither preventable nor treatable using currently available immunosuppression. Recent evidence has shown that innate immune stimuli are fundamental to the development of CLAD. Here, we examine long-standing assumptions and new concepts linking innate immune activation to late lung allograft fibrosis.
ISSN:2305-5839
2305-5839
DOI:10.21037/atm.2020.03.20