A review on myricetin as a potential therapeutic candidate for cancer prevention

Myricetin, one of the most extensively studied polyphenols, is present abundantly in various fruits and vegetables and exhibits diverse pharmacological properties. The multifaceted biological action of myricetin against tumor heterogeneity makes it an impressive anticancer agent whose efficacy has b...

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Bibliographic Details
Published in:3 Biotech 2020-05, Vol.10 (5), p.211, Article 211
Main Authors: Afroze, Nazia, Pramodh, Sreepoorna, Hussain, Arif, Waleed, Madiha, Vakharia, Kajal
Format: Article
Language:English
Subjects:
Agriculture
Angiogenesis
Anticancer properties
Apoptosis
Bioavailability
Bioinformatics
Biological properties
Biomaterials
Biotechnology
Cancer
Cancer Research
Cell growth
Cell proliferation
Chemistry
Chemistry and Materials Science
Conjugation
Heterogeneity
Metastases
Metastasis
Polyphenols
Review
Review Article
Stem Cells
Tumor suppressor genes
Tumors
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Summary:Myricetin, one of the most extensively studied polyphenols, is present abundantly in various fruits and vegetables and exhibits diverse pharmacological properties. The multifaceted biological action of myricetin against tumor heterogeneity makes it an impressive anticancer agent whose efficacy has been confirmed by an overwhelming number of studies. Myricetin shows its therapeutic potential by targeting and modulating the expression of various molecular target which are involved in inflammation, cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. Myricetin deters tumor progression by inducing apoptosis via both intrinsic and extrinsic pathway, activating/inactivating several signaling pathways, and reactivating various tumor suppressor genes. This comprehensive review represents the effect of myricetin on various hallmarks of cancer with insight into the molecular mechanism employed by myricetin to mitigate cell proliferation, angiogenesis, metastasis, and induce apoptosis. In addition, enhanced bioavailability of myricetin through conjugation and its increased efficacy as an anticancer agent when used in combination are also highlighted.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-020-02207-3