Clinical and genetic analysis of Human Bocavirus in children with lower respiratory tract infection in Taiwan

Abstract Background Human Bocavirus (HBoV) is a likely etiologic agent of acute respiratory disease in children. The prevalence of this virus has been studied in several sites worldwide. We conducted the first clinical and molecular study of HBoV in Taiwan at the Centers for Diseases Control, Taiwan...

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Bibliographic Details
Published in:Journal of clinical virology 2009-03, Vol.44 (3), p.219-224
Main Authors: Lin, Jih-Hui, Chiu, Shu-Chun, Lin, Yung-Cheng, Chen, Hsiu-Lin, Lin, Kuei-Hsiang, Shan, Kuo-Hao, Wu, Ho-Sheng, Liu, Hsin-Fu
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Allergy and Immunology
Biological and medical sciences
Bocavirus - classification
Bocavirus - genetics
Bocavirus - isolation & purification
Child
Child, Preschool
DNA, Viral - genetics
Female
Fundamental and applied biological sciences. Psychology
Genetics
Genotype
Human Bocavirus
Human viral diseases
Humans
Infant
Infectious Disease
Infectious diseases
LRTI
Male
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
Nasopharynx - virology
Parvoviridae Infections - epidemiology
Parvoviridae Infections - virology
Pharynx - virology
Phylogenetic analysis
Phylogeny
Prevalence
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Sequence Analysis, DNA
Taiwan
Taiwan - epidemiology
Viral diseases
Viral Proteins - genetics
Virology
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Summary:Abstract Background Human Bocavirus (HBoV) is a likely etiologic agent of acute respiratory disease in children. The prevalence of this virus has been studied in several sites worldwide. We conducted the first clinical and molecular study of HBoV in Taiwan at the Centers for Diseases Control, Taiwan. Objectives To investigate the genomic and epidemiologic profiles of HBoV infection in Taiwan. Study design Throat swabs or nasopharyngeal aspirates were obtained from hospitalized pediatric patients with acute lower respiratory tract infections. Specimens negative for other respiratory viruses by molecular screening were examined for HBoV. Results HBoV was the only virus detected in 30 (5.6%) of 531 samples. Of these positive cases, 56.7% were from children less than 2 years old. Two groups of HBoV co-circulated in Taiwan during the study. Results of evolutionary networks evaluation suggest that HBoV might have had an opportunity for interbreeding of viruses and genetic recombinations among the different genes. Conclusion HBoV may have circulated in Taiwan for some time and it appears to be one of the etiological agents responsible for lower respiratory tract infection in children.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2008.12.018