Prognostic relevance of telomere length and telomerase reverse transcriptase variant (rs2242652) on the multiple myeloma patients

Background The search for enhancement of multiple myeloma prognostic tools is an area of current research. This study aimed to assess the clinicopathological impact of telomere length and telomerase reverse transcriptase (TERT) polymorphic variant, rs2242652, on multiple myeloma (MM) patients. Metho...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2020-04, Vol.34 (4), p.e23133-n/a
Main Authors: Aref, Salah, Al Saeed, Alshaimaa, El Menshawy, Nadia, Abdalla, Doaa, El Ashery, Mohamed
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Bone marrow
Cancer
Case-Control Studies
Deoxyribonucleic acid
DNA
DNA polymerase
Female
Gene polymorphism
Genetic Predisposition to Disease
Genotyping
Hemoglobin
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Males
Middle Aged
Multiple myeloma
Multiple Myeloma - enzymology
Multiple Myeloma - genetics
Neoplasm Staging
Polymerase chain reaction
Polymorphism, Single Nucleotide - genetics
Prognosis
Proteins
Quality control
relative telomere length
Remission
Remission Induction
RNA-directed DNA polymerase
rs2242652
Software
Survival
Telomerase
Telomerase - genetics
Telomerase reverse transcriptase
Telomere Homeostasis - genetics
TERT
Thermal cycling
Working groups
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Summary:Background The search for enhancement of multiple myeloma prognostic tools is an area of current research. This study aimed to assess the clinicopathological impact of telomere length and telomerase reverse transcriptase (TERT) polymorphic variant, rs2242652, on multiple myeloma (MM) patients. Methods Fifty MM patients and 50 healthy controls were included. Relative telomere length (RTL) and rs2242652 genotype polymorphic variants of TERT were analyzed using real‐time polymerase chain reaction (PCR). The MM patients' group was categorized into stage I (n = 16); stage II (n = 12), and stage III (n = 22). Results The median telomere length was significantly longer in MM patients' group (0.78) as compared to controls (0.43) (P = .001). Multivariate regression analysis revealed that MM patients with RTL 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.23133