First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes enzymatic conversion of cortisone into the stress hormone cortisol. This first-in-human brain imaging study characterizes the kinetic modeling and test–retest reproducibility of [18F]AS2471907, a novel PET radiotracer for 11β-HSD1. Eight i...

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Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism 2020-04, Vol.40 (4), p.695-704
Main Authors:	Bhatt, Shivani, Nabulsi, Nabeel B, Li, Songye, Cai, Zhengxin, Matuskey, David, Bini, Jason, Najafzadeh, Soheila, Kapinos, Michael, Ropchan, Jim R, Carson, Richard E, Cosgrove, Kelly P, Huang, Yiyun, Hillmer, Ansel T
Format:	Article
Language:	eng
Subjects:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism Adult Brain - diagnostic imaging Brain - enzymology Female Fluorine Radioisotopes Humans Hydrocortisone - blood Kinetics Male Models, Biological Molecular Imaging - methods Original Positron-Emission Tomography - methods Radiopharmaceuticals - blood Radiopharmaceuticals - pharmacokinetics Tissue Distribution Triazoles - blood Triazoles - pharmacokinetics
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Summary:	11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes enzymatic conversion of cortisone into the stress hormone cortisol. This first-in-human brain imaging study characterizes the kinetic modeling and test–retest reproducibility of [18F]AS2471907, a novel PET radiotracer for 11β-HSD1. Eight individuals underwent one 180-min (n = 4) or two 240-min (n = 4) [18F]AS2471907 PET brain scans (12 total) acquired on the high-resolution research tomograph (HRRT) scanner with arterial blood sampling. Imaging data were modeled with 1-tissue (1T) and 2-tissue (2T) compartment models and with multilinear analysis (MA1) to estimate [18F]AS2471907 availability (VT). [18F]AS2471907 demonstrated high, heterogeneous uptake throughout the brain. Of the compartment models, 2T best described [18F]AS2471907 data. Estimates of VT were highly correlated between 2T and MA1 (t* = 30 min) with MA1 yielding VT values ranging from 3.2 ± 1.0 mL/cm3 in the caudate to 15.7 ± 4.2 mL/cm3 in the occipital cortex. The median absolute test–retest variability of 16 ± 5% and high intraclass correlation coefficient (ICC) values of 0.67–0.97 across regions indicate fair test–retest reliability but large intersubject variability. VT estimates using 180 min were within 10% of estimates using full acquisition time. In summary, [18F]AS2471907 exhibits reasonable kinetic properties for imaging 11β-HSD1 in human brain.
ISSN:	0271-678X 1559-7016