Human metapneumovirus in patients with respiratory tract infection in Kuwait

Human metapneumovirus (hMPV) has been recognized as an important cause of respiratory tract infections in all age groups and in all geographical area. The role of hMPV in causing respiratory tract infections in Kuwait was not yet investigated. The aim of this study was to determine the prevalence of...

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Bibliographic Details
Published in:Journal of medical virology 2011-10, Vol.83 (10), p.1811-1817
Main Authors: Al-Turab, Mariam, Chehadeh, Wassim, Al-Mulla, Fahd, Al-Nakib, Widad
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Adenoviridae - isolation & purification
Adenovirus
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
co-infection
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genotype
Human metapneumovirus
human metapneumovirus (hMPV)
Human viral diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Kuwait - epidemiology
Male
Medical sciences
Metapneumovirus - classification
Metapneumovirus - genetics
Metapneumovirus - isolation & purification
Microbiology
Middle Aged
Miscellaneous
Paramyxoviridae Infections - epidemiology
Paramyxoviridae Infections - virology
prevalence
Respiratory syncytial virus
Respiratory Syncytial Viruses - genetics
Respiratory Syncytial Viruses - isolation & purification
Respiratory System - virology
respiratory tract infections
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Rhinovirus
Rhinovirus - genetics
Rhinovirus - isolation & purification
RNA, Viral - analysis
Viral diseases
viral load
Virology
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Summary:Human metapneumovirus (hMPV) has been recognized as an important cause of respiratory tract infections in all age groups and in all geographical area. The role of hMPV in causing respiratory tract infections in Kuwait was not yet investigated. The aim of this study was to determine the prevalence of hMPV infection in Kuwait among patients with respiratory tract infection with respect to other respiratory viruses. During January–December 2009, 460 respiratory samples from 388 patients with respiratory tract infection were collected from different hospitals. They were tested for hMPV RNA by real‐time PCR, and for other respiratory viruses by conventional PCR. Out of 388 patients, 110 (28%) were positive for viral respiratory infections; 21 (5.4%) were positive for hMPV, 29 (7.5%) were positive for rhinovirus, 13 (4%) were positive for respiratory syncytial virus, and 10 (3%) were positive for adenovirus. Most (n = 19, 90.5%) of hMPV‐positive patients were admitted to the intensive care unit, 76% of them were of age 2 years and below, and 24% of age 59 years and above. All hMPV‐positive elderly patients had pneumonia while 50% of hMPV‐positive infants had bronchopneumonia. Children with hMPV/rhinovirus co‐infection (n = 3, 1%) had recurrent chest infection and frequent intensive care unit admission. The hMPV infection was mostly detected between December and May, and genotype B was more prevalent than genotype A. This is the first study demonstrating the prevalence of hMPV infection in Kuwait, and suggests that hMPV infection is prevalent in infants and elderly patients with lower respiratory tract infection. J. Med. Virol. 83:1811–1817, 2011. © 2011 Wiley‐Liss, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.22193