Diagnostic accuracy of two point‐of‐care kits for the diagnosis of Giardia species infection in dogs

OBJECTIVES: The objective of this study was to compare results obtained by ZnSO₄ Flotation and SNAP ®Giardia to those generated by the new point‐of‐care tests Single and Triple Rapid. METHODS: Prospective study evaluating 51 canine faecal samples submitted at a reference laboratory for the presence...

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Bibliographic Details
Published in:Journal of small animal practice 2016-06, Vol.57 (6), p.318-322
Main Authors: Costa, M., Clarke, C., Mitchell, S., Papasouliotis, K.
Format: Article
Language:English
Subjects:
Animals
Dog Diseases - diagnosis
Dogs
Giardia
Giardiasis - diagnosis
Giardiasis - veterinary
Point-of-Care Systems
Prospective Studies
Zinc Sulfate
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Summary:OBJECTIVES: The objective of this study was to compare results obtained by ZnSO₄ Flotation and SNAP ®Giardia to those generated by the new point‐of‐care tests Single and Triple Rapid. METHODS: Prospective study evaluating 51 canine faecal samples submitted at a reference laboratory for the presence of Giardia spp. Kappa statistics, specificity, sensitivity, positive predictive value (PPV) and negative predictive value (NPV) were calculated by comparing the new tests to the combined results of ZnSO₄ and SNAP tests. RESULTS: There was fair (Single Rapid, j=0·434) to good (Triple Rapid, j =0·797) agreement with the reference tests. At this study's prevalence (59 to 61%), specificities and PPV were high (1·00) with both Rapid tests, but sensitivities and NPV were lower for the Single than for the Triple (0·48 vs 0·83 and 0·55 vs 0·80) tests. At lower prevalence rates, both tests exhibited a high PPV (1·00), but the NPV were higher with the Triple (0·96 to 0·99) than the Single (0·88 to 0·96) Rapid test. CLINICAL SIGNIFICANCE: Both tests exhibited excellent PPV values at all prevalence rates but an excellent NPV only at low prevalence. As the prevalence is likely to be low (
ISSN:0022-4510
1748-5827
DOI:10.1111/jsap.12475