Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV...

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Published in:	The Lancet 2020-02, Vol.395 (10223), p.507-513
Main Authors:	Chen, Nanshan, Zhou, Min, Dong, Xuan, Qu, Jieming, Gong, Fengyun, Han, Yang, Qiu, Yang, Wang, Jingli, Liu, Ying, Wei, Yuan, Xia, Jia'an, Yu, Ting, Zhang, Xinxin, Zhang, Li
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over China - epidemiology Clustering Comorbidity Coronaviridae Coronavirus Infections - complications Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronavirus Infections - therapy Coronaviruses Cough Cough - epidemiology Cough - virology COVID-19 Diarrhea Disease Outbreaks Dyspnea - epidemiology Dyspnea - virology Epidemiology Fatalities Female Fever Fever - epidemiology Fever - virology Headache Health risks Humans Infections Male Males Men Middle Aged Mortality Muscles Nausea Nose Opacity Pain Patients Pharyngitis Pharynx Pneumonia Pneumonia, Viral - complications Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Pneumonia, Viral - therapy Pneumothorax Polymerase chain reaction Prognosis Radiography, Thoracic Real time Respiratory diseases Respiratory distress syndrome Retrospective Studies Seafood Severe Acute Respiratory Syndrome - epidemiology Severe Acute Respiratory Syndrome - virology Tomography, X-Ray Computed Viruses Vomiting Young Adult
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Summary:	In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020. Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55·5 years (SD 13·1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). According to imaging examination, 74 (75%) patients showed bilateral pneumonia, 14 (14%) patients showed multiple mottling and ground-glass opacity, and one (1%) patient had pneumothorax. 17 (17%) patients developed acute respiratory distress syndrome and, among them, 11 (11%) patients worsened in a short period of time and died of multiple organ failure. The 2019-nCoV infection was of clustering onset, is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In general, characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia. Further investigation is needed to explore the applicability of the MuLBSTA score in predicting the risk of mortality in 2019-nCoV infection. National Key R&D Program of China.
ISSN:	0140-6736 1474-547X