IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection

•An exacerbated activation of IL-33/ST2 axis was associated with severity of viral ALRI.•Detectable NPA IL-33 and sST-2 levels were risk factors for mechanical ventilation.•An increment in NPA sST2 levels was associated with longer hospital length of stay.•A systemic increase in IL-33 concentrations...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2020-03, Vol.127, p.154965-154965, Article 154965
Main Authors: Portugal, Carolina Augusta Arantes, de Araújo Castro, Ítalo, Prates, Mirela Cristina Moreira, Gagliardi, Talita Bianca, Martins, Ronaldo Bragança, de Jesus, Bruna Laís Santos, de Souza Cardoso, Ricardo, da Silva, Marcus Vinícius Gomes, Aragon, Davi Casale, Arruda Neto, Eurico, Alves Filho, José Carlos Farias, Cunha, Fernando de Queiroz, Carlotti, Ana Paula de Carvalho Panzeri
Format: Article
Language:English
Subjects:
Acute lower respiratory infection
Inflammatory cytokines
Interleukin 33
Respiratory viruses
Soluble suppression of tumorigenicity 2
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Summary:•An exacerbated activation of IL-33/ST2 axis was associated with severity of viral ALRI.•Detectable NPA IL-33 and sST-2 levels were risk factors for mechanical ventilation.•An increment in NPA sST2 levels was associated with longer hospital length of stay.•A systemic increase in IL-33 concentrations was associated with milder disease. Mechanisms influencing severity of acute lower respiratory infection (ALRI) in children are not established. We aimed to assess the role of inflammatory markers and respiratory viruses in ALRI severity. Concentrations of interleukin(IL)-33, soluble suppression of tumorigenicity (sST)2, IL-1ß, tumor necrosis factor α, IL-4, IL-6 and IL- 8 and types of respiratory viruses were evaluated in children at the first and fifth days after hospital admission. Disease severity was defined as need for mechanical ventilation. Seventy-nine children
ISSN:1043-4666
1096-0023
1096-0023
DOI:10.1016/j.cyto.2019.154965