Transmission Dynamics and Prospective Environmental Sampling of Adenovirus in a Military Recruit Setting

BackgroundHigh levels of morbidity caused by adenovirus among US military recruits have returned since the loss of adenovirus vaccines in 1999. The transmission dynamics of adenovirus have never been well understood, which complicates prevention efforts MethodsEnrollment and end-of-study samples wer...

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Bibliographic Details
Published in:The Journal of Infectious Diseases 2006-10, Vol.194 (7), p.877-885
Main Authors: Russell, Kevin L., Broderick, Michael P., Franklin, Suzanne E., Blyn, Lawrence B., Freed, Nikki E., Moradi, Emily, Ecker, David J., Kammerer, Peter E., Osuna, Miguel A., Kajon, Adriana E., Morn, Cassandra B., Ryan, Margaret A. K.
Format: Article
Language:English
Subjects:
Adenovirus
Adenovirus Infections, Human - transmission
Adenovirus Infections, Human - virology
Adenoviruses
Adenoviruses, Human - classification
Adenoviruses, Human - genetics
Adenoviruses, Human - immunology
Adenoviruses, Human - isolation & purification
Air sampling
Antibodies
Antibodies, Viral - blood
Cell Line, Tumor
Diseases
Housing
Humans
Infections
Major
Military Personnel
Military recruitment
Military training
Respiratory diseases
Respiratory Tract Infections - transmission
Respiratory Tract Infections - virology
Surveillance
United States
Vaccination
Viruses
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Summary:BackgroundHigh levels of morbidity caused by adenovirus among US military recruits have returned since the loss of adenovirus vaccines in 1999. The transmission dynamics of adenovirus have never been well understood, which complicates prevention efforts MethodsEnrollment and end-of-study samples were obtained and active surveillance for febrile respiratory illnesses (FRIs) was performed for 341 recruits and support personnel. Environmental samples were collected simultaneously. Classic and advanced diagnostic techniques were used ResultsSeventy-nine percent (213/271) of new recruits were seronegative for either adenovirus serotype 4 (Ad-4) or adenovirus serotype 7 (Ad-7). FRI caused by Ad-4 was observed in 25% (67/271) of enrolled recruits, with 100% of them occurring in individuals with enrollment titers
ISSN:0022-1899
1537-6613
DOI:10.1086/507426