The ubiquitous role of ubiquitin in the DNA damage response

Protein ubiquitylation has emerged as an important regulatory mechanism that impacts almost every aspect of the DNA damage response. In this review, we discuss how DNA repair and checkpoint pathways utilize the diversity offered by the ubiquitin conjugation system to modulate the response to genotox...

Full description

Saved in:
Bibliographic Details
Published in:DNA repair 2010-12, Vol.9 (12), p.1229-1240
Main Authors: Al-Hakim, Abdallah, Escribano-Diaz, Cristina, Landry, Marie-Claude, O’Donnell, Lara, Panier, Stephanie, Szilard, Rachel K., Durocher, Daniel
Format: Article
Language:English
Subjects:
DNA Breaks, Double-Stranded
DNA Repair - genetics
DNA Repair - physiology
DNA-Binding Proteins - metabolism
Fanconi Anemia Complementation Group Proteins - metabolism
Genes, cdc - physiology
Proteasome Endopeptidase Complex - metabolism
Signal Transduction - genetics
Signal Transduction - physiology
Ubiquitin - metabolism
Ubiquitin-Protein Ligases - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Protein ubiquitylation has emerged as an important regulatory mechanism that impacts almost every aspect of the DNA damage response. In this review, we discuss how DNA repair and checkpoint pathways utilize the diversity offered by the ubiquitin conjugation system to modulate the response to genotoxic lesions in space and time. In particular, we will highlight recent work done on the regulation of DNA double-strand breaks signalling and repair by the RNF8/RNF168 E3 ubiquitin ligases, the Fanconi anemia pathway and the role of protein degradation in the enforcement and termination of checkpoint signalling. We also discuss the various functions of deubiquitylating enzymes in these processes along with potential avenues for exploiting the ubiquitin conjugation/deconjugation system for therapeutic purposes.
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2010.09.011