An Unusual Case of the Successful Treatment of Carbapenem-resistant Ventriculitis with Intravenous Colistin

Ventriculitis is a well-documented complication of ventriculostomy, which is difficult to treat and is associated with high rates of mortality. There is a growing trend of resistance among many organisms, such as Acinetobacter baumannii, in particular, to most antibiotics with the exception of colis...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-02, Vol.12 (2), p.e7120
Main Authors: Abu Bakar, Azizi, Palaniandy, Kamalanathan, Fadzil, Farizal, Jaafar, Ainul Syahril, Paramasvaran, Sanmugarajah
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Blood-brain barrier
Case reports
Catheters
Contusions
Infectious Disease
Mortality
Multidrug resistant organisms
Nervous system
Neurosurgery
Nosocomial infections
Patients
Polypeptides
Staphylococcus infections
Trauma
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Summary:Ventriculitis is a well-documented complication of ventriculostomy, which is difficult to treat and is associated with high rates of mortality. There is a growing trend of resistance among many organisms, such as Acinetobacter baumannii, in particular, to most antibiotics with the exception of colistin. It is thought that colistin has poor blood-brain barrier penetration; therefore, in cases of ventriculitis, it is preferentially administered via the intrathecal or intraventricular route. These routes, in turn, risk introducing infections, which may perpetuate the problem. We report a case of multidrug-resistant Acinetobacter baumannii ventriculitis, which was treated successfully with intravenous colistin monotherapy.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.7120