The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients

Objective This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020. Methods The clinical and laboratory findings were extracted from the e...

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Bibliographic Details
Published in:	Inflammation research 2020-06, Vol.69 (6), p.599-606
Main Authors:	Yuan, Jing, Zou, Rougrong, Zeng, Lijiao, Kou, Shanglong, Lan, Jianfeng, Li, Xiaohe, Liang, Yanhua, Ding, Xiaoyan, Tan, Guoyu, Tang, Shenghong, Liu, Lei, Liu, Yingxia, Pan, Yanchao, Wang, Zhaoqin
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Aged Allergology Biomedical and Life Sciences Biomedicine C-reactive protein Child Child, Preschool China Coronavirus Infections - blood Coronavirus Infections - drug therapy Coronavirus Infections - physiopathology Coronavirus Infections - virology Coronaviruses Correlation analysis COVID-19 Creatine Creatine kinase Creatine Kinase - blood Dermatology Drug Combinations Electronic health records Electronic medical records Health services Humans Immunology Infections Interferon Interferon-alpha - therapeutic use Interleukin 6 Kinases L-Lactate dehydrogenase L-Lactate Dehydrogenase - blood Laboratories Lactate dehydrogenase Lactic acid Lopinavir Lopinavir - therapeutic use Medical treatment Middle Aged mRNA Neurology Original Research Paper Pandemics Patients Pharmacology/Toxicology Physicians Pneumonia, Viral - blood Pneumonia, Viral - drug therapy Pneumonia, Viral - physiopathology Pneumonia, Viral - virology Polymerase Chain Reaction Retrospective Studies Rheumatology Ribavirin Ritonavir Ritonavir - therapeutic use RNA, Viral - analysis Signs and symptoms Viral diseases Viruses Young Adult α-Interferon
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Summary:	Objective This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020. Methods The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. Results COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin. Conclusions Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection.
ISSN:	1023-3830 1420-908X