Prediction of Survival After Liver Transplantation for Chronic Severe Hepatitis B Based on Preoperative Prognostic Scores: A Single Center’s Experience in China

Background The aim of this study was to estimate the utility of a preoperative model of end-stage liver disease (MELD) score and Child-Turcotte-Pugh (CTP) score in predicting the prognosis after othotopic liver transplantation (OLT) for chronic severe hepatitis B (CSHB) and explore the prognostic fa...

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Bibliographic Details
Published in:World journal of surgery 2009-11, Vol.33 (11), p.2420-2426
Main Authors: Xiao, Liang, Fu, Zhi-Ren, Ding, Guo-Shan, Fu, Hong, Ni, Zhi-Jia, Wang, Zheng-Xin, Shi, Xiao-Min, Guo, Wen-Yuan, Ma, Jun
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Biological and medical sciences
Cardiac Surgery
China
Cold Ischemia Time
Female
General aspects
General Surgery
Hepatic Artery Thrombosis
Hepatic Encephalopathy
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - surgery
Hepatorenal Syndrome
Human viral diseases
Humans
Infectious diseases
Liver Failure - etiology
Liver Transplantation - mortality
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Poor Graft Function
Prognosis
Risk Factors
Severity of Illness Index
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Survival Analysis
Thoracic Surgery
Treatment Outcome
Vascular Surgery
Viral diseases
Viral hepatitis
Young Adult
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Summary:Background The aim of this study was to estimate the utility of a preoperative model of end-stage liver disease (MELD) score and Child-Turcotte-Pugh (CTP) score in predicting the prognosis after othotopic liver transplantation (OLT) for chronic severe hepatitis B (CSHB) and explore the prognostic factors. Methods The outcome of 137 patients who underwent OLT using donors after cardiac death (DCDs) for CSHB in our center was reviewed retrospectively. Survival analysis was performed using the Kaplan-Meier method; the log-rank test was used for univariate analysis; and the Cox proportional hazards regression model was used for prognostic factors screening. Results The overall mortality rate was 33.6% (46/137); and 1-month, 6-month, 1-year, and 5-year patient survival rates were 75.8, 72.0, 71.0, and 60.1%, respectively. Most patients (33/46) died during the first month after OLT. The area under the curve values generated by the receiver operating characteristics curves were 0.82 [95% confidence interval (CI) 0.72–0.92] and 0.68 (95% CI 0.58–0.79), respectively ( P  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-009-0183-3