Relationship between herpesviruses and periodontal disease progression

Aim To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis. Methods Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or po...

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Bibliographic Details
Published in:Journal of clinical periodontology 2020-04, Vol.47 (4), p.442-450
Main Authors: Emecen‐Huja, Pinar, Danaher, Robert J., Dawson, Dolphus R., Wang, Chunmei, Kryscio, Richard J., Ebersole, Jeffrey L., Miller, Craig S.
Format: Article
Language:English
Subjects:
Adult
Anaerobic bacteria
Bacteria
Copy number
Cytomegalovirus
Disease Progression
Epstein-Barr virus
Epstein–Barr virus infections
Fish oils
Gum disease
Herpesviridae
Herpesvirus 4, Human
Humans
Oral hygiene
Periodontal diseases
Periodontitis
Polymerase chain reaction
Polyunsaturated fatty acids
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Summary:Aim To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis. Methods Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or polyunsaturated fatty acids fish oil. Subgingival plaque samples collected from three healthy and three disease sites at weeks 0, 16, and 28 and from sites demonstrating disease progression were analysed for EBV, CMV, P. gingivalis (Pg), T. forsythia (Tf), and T. denticola (Td) DNA using quantitative polymerase chain reaction. Results Cytomegalovirus was detected in 0.3% (4/1454) sites. EBV was present in 12.2% of healthy sites (89/728) and 27.6% disease sites (201/726; p 
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.13239