Predictive factors of death in primary lung cancer patients on admission to the intensive care unit

To assess the lung cancer patient's prognosis in the intensive care unit with early predictive factors of death. Retrospective study from July 1986 to February 1996. Medical intensive care unit at a university hospital. Fifty-seven patients with primary lung cancer admitted to our medical inten...

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Bibliographic Details
Published in:Intensive care medicine 2000-12, Vol.26 (12), p.1811-1816
Main Authors: BOUSSAT, S, EL'RINI, T, DUBIEZ, A, DEPIERRE, A, BARALE, F, CAPELLIER, G
Format: Article
Language:English
Subjects:
Activities of Daily Living
Acute Disease
Aged
APACHE
Biological and medical sciences
Hospital Mortality
Humans
Intensive Care Units - statistics & numerical data
Lung cancer
Lung Neoplasms - classification
Lung Neoplasms - complications
Lung Neoplasms - mortality
Medical sciences
Middle Aged
Multiple Organ Failure - etiology
Multivariate Analysis
Neoplasm Staging
Original
Patient Admission - statistics & numerical data
Pneumology
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Severity of Illness Index
Survival Analysis
Tumors of the respiratory system and mediastinum
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Summary:To assess the lung cancer patient's prognosis in the intensive care unit with early predictive factors of death. Retrospective study from July 1986 to February 1996. Medical intensive care unit at a university hospital. Fifty-seven patients with primary lung cancer admitted to our medical intensive care unit (MICU). Data collection included demographic data (age, sex, underlying diseases, MICU admitting diagnosis) and evaluation of tumor (pathologic subtypes, metastases, lung cancer staging, treatment options). Three indexes were calculated for each patient: Karnofsky performance status, Simplified Acute Physiology Score (SAPS) II, and multisystem organ failure score (ODIN score). Mortality was high in the MICU: 66% of patients died during their MICU stay, and hospital mortality reached 75%. In multivariate analysis, acute pulmonary disease and Karnofsky performance status < 70 were associated with a poor MICU and post-MICU prognosis. For the survivors, long-term survival after MICU discharge depended exclusively on the severity of the lung cancer. We confirmed the high mortality rate of lung cancer patients admitted to the MICU. Two predictive factors of death in MICU were identified: performance status < 70 and acute pulmonary disease.
ISSN:0342-4642
1432-1238
DOI:10.1007/s001340000701