Viral and Mycoplasma pneumoniae community-acquired pneumonia and novel clinical outcome evaluation in ambulatory adult patients in China

Few studies have addressed the etiology and clinical outcomes of community-acquired pneumonia (CAP) treated in an ambulatory setting. We investigated the etiology by the culture of Mycoplasma pneumoniae, urine antigen testing of Streptococcus pneumoniae and Legionella pneumoniae, and DNA or RNA dete...

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Published in:	European journal of clinical microbiology & infectious diseases 2010-11, Vol.29 (11), p.1443-1448
Main Authors:	Cao, B, Ren, L.-L, Zhao, F, Gonzalez, R, Song, S.-F, Bai, L, Yin, Y. D, Zhang, Y.-Y, Liu, Y.-M, Guo, P, Zhang, J.-Z, Wang, J.-W, Wang, C
Format:	Article
Language:	eng
Subjects:	Adenovirus Adult Age Factors Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use beta-Lactams - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Brief Report China - epidemiology Community-Acquired Infections - drug therapy Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Community-Acquired Infections - virology Female Human metapneumovirus Humans Infectious diseases Influenza A virus Internal Medicine Legionella Legionella pneumophila - isolation & purification Macrolides - therapeutic use Male Medical Microbiology Medical sciences Middle Aged Mycoplasma pneumoniae Mycoplasma pneumoniae - isolation & purification Parainfluenza virus Pneumology Pneumonia, Bacterial - diagnosis Pneumonia, Bacterial - drug therapy Pneumonia, Bacterial - epidemiology Pneumonia, Bacterial - microbiology Pneumonia, Mycoplasma - diagnosis Pneumonia, Mycoplasma - drug therapy Pneumonia, Mycoplasma - epidemiology Pneumonia, Mycoplasma - microbiology Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Pneumonia, Viral - virology Quinolones - therapeutic use Respiratory system : syndromes and miscellaneous diseases Sputum - microbiology Streptococcus pneumoniae Streptococcus pneumoniae - isolation & purification Treatment Outcome
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Summary:	Few studies have addressed the etiology and clinical outcomes of community-acquired pneumonia (CAP) treated in an ambulatory setting. We investigated the etiology by the culture of Mycoplasma pneumoniae, urine antigen testing of Streptococcus pneumoniae and Legionella pneumoniae, and DNA or RNA determination of eight kinds of respiratory virus DNA or RNA. An etiological diagnosis was made in 51.8% of 197 patients. The most common pathogens were M. pneumoniae (29.4%) followed by influenza virus A, parainfluenza virus, adenovirus, human metapneumovirus (9.6%), and S. pneumoniae (4.1%). Patients with mycoplasma infections were younger, less likely to have comorbidities, and less likely to have adequate sputum for gram stain and culture. Patients with viral infections were older and more likely to have poorly defined nodules on chest X-ray (CXR) or computed tomography (CT) scan. Among patients infected with M. pneumoniae, those with quinolones as initial prescriptions had shorter duration of fever after the initiation of antibiotics than patients with β-lactams, macrolides, or β-lactams + macrolides (p
ISSN:	0934-9723 1435-4373