Aetiology of community-acquired pneumonia among adults in an H1N1 pandemic year: the role of respiratory viruses

This study aimed to determine the aetiology of community-acquired pneumonia (CAP) by adding polymerase chain reaction (PCR) to conventional methods and to describe the clinical and laboratory features between patients with bacterial pneumonia (BP) and viral pneumonia (VP). Adults with CAP admitted f...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2012-10, Vol.31 (10), p.2765-2772
Main Authors: Sangil, A., Calbo, E., Robles, A., Benet, S., Viladot, M. E., Pascual, V., Cuchí, E., Pérez, J., Barreiro, B., Sánchez, B., Torres, J., Canales, L., De Marcos, J. A., Garau, J.
Format: Article
Language:English
Subjects:
Adenoviruses
Aged
Aged, 80 and over
Bacterial Typing Techniques
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blood
Bordetella pertussis
Bordetella pertussis - genetics
Bordetella pertussis - isolation & purification
C-reactive protein
Chlamydophila pneumoniae
Chlamydophila pneumoniae - genetics
Chlamydophila pneumoniae - isolation & purification
Coinfection - epidemiology
Coinfection - microbiology
Coinfection - virology
Community-Acquired Infections - diagnosis
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Community-Acquired Infections - virology
Demographics
Demography
Etiology
Female
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Hospitals
Humans
Infection
Infectious diseases
Influenza
Influenza A Virus, H1N1 Subtype
Influenza, Human - epidemiology
Influenza, Human - virology
Internal Medicine
Legionella pneumophila
Legionella pneumophila - genetics
Legionella pneumophila - isolation & purification
Male
Medical Microbiology
Medical sciences
Middle Aged
Mortality
Multiplex Polymerase Chain Reaction
Mycoplasma pneumoniae
Mycoplasma pneumoniae - genetics
Mycoplasma pneumoniae - isolation & purification
Pandemics
Pathogens
Pertussis
Pneumology
Pneumonia
Pneumonia, Bacterial - diagnosis
Pneumonia, Bacterial - epidemiology
Pneumonia, Bacterial - microbiology
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - virology
Polymerase chain reaction
procalcitonin
Prospective Studies
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus, Human - isolation & purification
Respiratory Syncytial Virus, Human - pathogenicity
Respiratory system : syndromes and miscellaneous diseases
Seasons
Severity of Illness Index
Shock
Spain - epidemiology
Sputum
Tuberculosis
Viral infections
Viruses
Whooping cough
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to determine the aetiology of community-acquired pneumonia (CAP) by adding polymerase chain reaction (PCR) to conventional methods and to describe the clinical and laboratory features between patients with bacterial pneumonia (BP) and viral pneumonia (VP). Adults with CAP admitted from November 2009 to October 2010 were included. Demographics, comorbidities, severity and clinical features were recorded. Conventional microbiological methods included blood and sputum cultures, acute and convalescent serologic samples, and antigen urinary detection. New methods included multiplex PCR for Mycoplasma pneumoniae , Legionella pneumophila , Chlamydophila pneumoniae , Bordetella pertussis and 15 respiratory viruses. A total of 169 patients were included. Using conventional methods, we identified a pathogen in 51 % of cases. With PCR, up to 70 % of cases had an aetiological diagnosis. Forty-five patients had BP (34 %), 22 had VP (17 %) and 25 (19 %) had co-infection (BP and VP). Pneumococci and respiratory syncytial virus (RSV) were the most frequently identified pathogens. Procalcitonin (PCT) and C-reactive protein (CRP) median values were significantly higher in BP than in VP patients. Shaking chills, higher CURB score and shock were significantly more frequent in BP. A viral infection was identified in more than one-third of patients with CAP. Clinical and laboratory features could help to differentiate between VP and BP and to guide empirical therapy.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-012-1626-6