Multi-Systemic Biological Risk and Cancer Mortality: The NHANES III Study

Multi-systemic biological risk (MSBR), a proxy for allostatic load, is a composite index of biomarkers representing dysregulation due to responses to chronic stress. This study examined the association of an MSBR index with cancer mortality. The sample included n = 13,628 adults aged 20-90 from the...

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Bibliographic Details
Published in:Scientific reports 2020-03, Vol.10 (1), p.5047-5047, Article 5047
Main Authors: Acheampong, Teofilia, Jiang, Luohua, Ziogas, Argyrios, Odegaard, Andrew O
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Allostasis
Blood Pressure
Body Mass Index
Body weight
C-Reactive Protein
Cancer
Female
Health risk assessment
Humans
Leukocyte Count
Male
Middle Aged
Mortality
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - mortality
Neoplasms - prevention & control
Overweight
Proportional Hazards Models
Pulse
Risk
Stress, Physiological
Stress, Psychological
Triglycerides
Triglycerides - metabolism
Waist Circumference
Young Adult
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Summary:Multi-systemic biological risk (MSBR), a proxy for allostatic load, is a composite index of biomarkers representing dysregulation due to responses to chronic stress. This study examined the association of an MSBR index with cancer mortality. The sample included n = 13,628 adults aged 20-90 from the NHANES III Linked Mortality File (1988-1994). The MSBR index included autonomic (pulse rate, blood pressure), metabolic (HOMA , triglycerides, waist circumference), and immune (white blood cell count, C-reactive protein) markers. We fit Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) of overall cancer mortality risk, according to quartiles (q) of the index. In multivariable models, compared to those in q1, q4 had a 64% increased risk for cancer mortality (HR = 1.64, 95% CI:1.13-2.40). The immune domain drove the association (HR per unit = 1.19, 95% CI:1.07-1.32). In stratified analyses, the HR for those with a BMI ≥ 25 was 1.12 per unit (95% CI:1.05-1.19) and those with a BMI 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-61945-9