Fractional Flow on TOF-MRA as a Measure of Stroke Risk in Children with Intracranial Arterial Stenosis

Conventional angiography is the criterion standard for measuring intracranial arterial stenosis. We evaluated signal intensity ratios from TOF-MRA as a measure of intracranial stenosis and infarct risk in pediatric stroke. A retrospective study was undertaken in children with intracranial arterial s...

Full description

Saved in:
Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2020-03, Vol.41 (3), p.535-541
Main Authors: Ibrahim, A Y, Amirabadi, A, Shroff, M M, Dlamini, N, Dirks, P, Muthusami, P
Format: Article
Language:English
Subjects:
Adolescent
Algorithms
Carotid Stenosis - complications
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - pathology
Child
Female
Humans
Infant
Magnetic Resonance Angiography - methods
Male
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - pathology
Pediatrics
Retrospective Studies
ROC Curve
Sensitivity and Specificity
Stroke - etiology
Stroke - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Conventional angiography is the criterion standard for measuring intracranial arterial stenosis. We evaluated signal intensity ratios from TOF-MRA as a measure of intracranial stenosis and infarct risk in pediatric stroke. A retrospective study was undertaken in children with intracranial arterial stenosis, who had TOF-MRA and conventional angiography performed within 6 months. Arterial diameters were measured for percentage stenosis. ROI analysis on TOF-MRA measured signal intensity in pre- and poststenotic segments, with post-/pre-signal intensity ratios calculated. The Pearson correlation was used to compare percentage stenosis on MRA with conventional angiography and signal intensity ratios with percentage stenosis; the point-biserial correlation was used for infarcts compared with percentage stenosis and signal intensity ratios. Sensitivity, specificity, and positive and negative predictive values were calculated for determining severe (≥70%) stenosis from MRA and signal intensity ratios against the criterion standard conventional angiography. 1.00: 97.1%, 77.8%, 71.7%, and 97.4%; combination: 75.5%, 100%, 100%, and 76.8%, respectively. Signal intensity ratios decreased with increasing grade of stenosis (none/mild-moderate/severe/complete,
ISSN:0195-6108
1936-959X
DOI:10.3174/AJNR.A6441