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Immune‐Related Adverse Events in the Setting of PD‐1/L1 Inhibitor Combination Therapy

In 2018, a multi‐disciplinary workshop was held at the Massachusetts General Hospital to discuss challenges in defining, diagnosing, and treating immune‐related adverse events (irAE), including those that occur in patients administered PD‐1/L1 inhibitor combination therapy. In this commentary, the w...

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Bibliographic Details
Published in:The oncologist (Dayton, Ohio) Ohio), 2020-03, Vol.25 (3), p.e398-e404
Main Authors: Zubiri, Leyre, Allen, Ian M., Taylor, Martin S., Guidon, Amanda C., Chen, Steven T., Schoenfeld, Sara R., Neilan, Tomas G., Sise, Meghan E., Mooradian, Meghan J., Rubin, Krista M., Leaf, Rebecca Karp, Parikh, Aparna R., Faje, Alexander, Gainor, Justin F., Cohen, Justine V., Fintelmann, Florian J., Kohler, Minna J., Dougan, Michael, Reynolds, Kerry L.
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Language:English
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Summary:In 2018, a multi‐disciplinary workshop was held at the Massachusetts General Hospital to discuss challenges in defining, diagnosing, and treating immune‐related adverse events (irAE), including those that occur in patients administered PD‐1/L1 inhibitor combination therapy. In this commentary, the workshop participants present a clinical case that illustrates the complexity of irAE diagnosis and management in a patient receiving PD‐1/L1 combination therapy, summarize the current state of PD‐1/L1 combination therapy, and discuss challenges and opportunities for the evaluation of irAEs as these combinations become more widely used to treat patients with cancer.
ISSN:1083-7159
1549-490X
1549-490X
DOI:10.1634/theoncologist.2018-0883