Glial Factors Regulating White Matter Development and Pathologies of the Cerebellum

The cerebellum is a brain region that undergoes extremely dynamic growth during perinatal and postnatal development which is regulated by the proper interaction between glial cells and neurons with a complex concert of growth factors, chemokines, cytokines, neurotransmitters and transcriptions facto...

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Bibliographic Details
Published in:Neurochemical research 2020-03, Vol.45 (3), p.643-655
Main Authors: Revuelta, Miren, Scheuer, Till, Chew, Li-Jin, Schmitz, Thomas
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Central nervous system
Cerebellum
Cerebellum - pathology
Chemokines
Circuits
Cognition
Cytokines
Glial cells
Growth factors
Humans
Motor task performance
Neurochemistry
Neurodegenerative diseases
Neurodevelopmental disorders
Neuroglia - pathology
Neurology
Neuronal-glial interactions
Neurosciences
Neurotransmitters
Original Paper
Signal Transduction
Signs and symptoms
Substantia alba
Transcription factors
White Matter - pathology
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Summary:The cerebellum is a brain region that undergoes extremely dynamic growth during perinatal and postnatal development which is regulated by the proper interaction between glial cells and neurons with a complex concert of growth factors, chemokines, cytokines, neurotransmitters and transcriptions factors. The relevance of cerebellar functions for not only motor performance but also for cognition, emotion, memory and attention is increasingly being recognized and acknowledged. Since perturbed circuitry of cerebro-cerebellar trajectories can play a role in many central nervous system pathologies and thereby contribute to neurological symptoms in distinct neurodevelopmental and neurodegenerative diseases, is it the aim with this mini-review to highlight the pathways of glia–glia interplay being involved. The designs of future treatment strategies may hence be targeted to molecular pathways also playing a role in development and disease of the cerebellum.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-020-02961-z