Incidence of and Risk factors for Mild Cognitive Impairment in Chinese Older Adults with Multimorbidity in Hong Kong

The aim of our study was to identify the incidence rate of and the risk factors for mild cognitive impairment (MCI) among Chinese older adults with multimorbidity in primary care in Hong Kong. Older adults aged 60 years and above with multimorbidity were recruited from the public primary care clinic...

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Bibliographic Details
Published in:Scientific reports 2020-03, Vol.10 (1), p.4137-4137, Article 4137
Main Authors: Xu, Zijun, Zhang, Dexing, Sit, Regina W S, Wong, Carmen, Tiu, Jennifer Y S, Chan, Dicken C C, Sun, Wen, Wong, Samuel Y S
Format: Article
Language:English
Subjects:
Asian People
Cognitive ability
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - physiopathology
Comorbidity
Female
Hong Kong - epidemiology
Humans
Incidence
Male
Multimorbidity
Older people
Primary care
Regression analysis
Risk Factors
Sensitivity analysis
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Summary:The aim of our study was to identify the incidence rate of and the risk factors for mild cognitive impairment (MCI) among Chinese older adults with multimorbidity in primary care in Hong Kong. Older adults aged 60 years and above with multimorbidity were recruited from the public primary care clinics in Hong Kong. Incidence rates were calculated with the person-years. Cox proportional hazard regression models were used to predict the risk factors for MCI. Sensitivity analysis was performed using multiple imputation. Among 462 participants included in the main analysis, 45 progressed from normal to MCI with an incidence rate of 80.9 cases per 1000 person-years. Older age (HR 2.82, 95% CI 1.26-6.28) and being single (HR 2.15, 95% CI 1.11-4.19) were risk factors for developing MCI in the multivariable regression model. A total of 660 participants were included in the sensitivity analysis, with an MCI incidence of 114.4 cases per 1000 person-years. Older age and being single remained to be risk factors for MCI among older adults with multimorbidity. There may be a high incidence of MCI among Chinese older adults with multimorbidity in primary care in Hong Kong. Future larger studies need to confirm the prevalence and incidence of MCI among primary care Chinese patients.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-60901-x