Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

The objectives of this study were to define the associations among single nucleotide polymorphisms (SNPs) of metastasis-associated in colon cancer-1 ( ) gene, development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwan. Genotypic frequencies of 5 SN...

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Bibliographic Details
Published in:International journal of medical sciences 2020-01, Vol.17 (4), p.490-497
Main Authors: Sun, Yi-Hung, Chou, Ying-Hsiang, Ou, Chu-Chyn, Ng, Soo-Cheen, Shen, Huang-Pin, Lee, Yueh-Chun, Hsu, Chun-Fang, Yang, Shun-Fa, Wang, Po-Hui
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Asian Continental Ancestry Group
Cervical cancer
Cervix
Colorectal cancer
Confidence intervals
Deoxyribonucleic acid
DNA
Equilibrium
Female
Gene expression
Genetic Predisposition to Disease - genetics
Genotype
Genotype & phenotype
Humans
Medical prognosis
Metastasis
Middle Aged
Patients
Polymerase Chain Reaction
Polymorphism, Single Nucleotide - genetics
Research Paper
Retrospective Studies
Statistical analysis
Survival Rate
Taiwan
Trans-Activators - genetics
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
Variance analysis
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Summary:The objectives of this study were to define the associations among single nucleotide polymorphisms (SNPs) of metastasis-associated in colon cancer-1 ( ) gene, development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwan. Genotypic frequencies of 5 SNPs rs975263, rs3095007, rs4721888, rs3735615 and rs1990172 were identified for 132 patients with invasive cancer, 99 with high-grade cervical intraepithelial neoplasia and 338 normal controls using real-time polymerase chain reaction. It revealed that there were no associations of these SNPs with cervical carcinogenesis. In the meantime, cervical cancer patients with genotype GG in SNP rs975263 tended to display more risk to have vaginal invasion than those with AA/AG ( =0.042, OR: 8.70, 95% CI: 0.81-433.22). In multivariate analysis, positive pelvic lymph node metastasis could significantly predict worse 5 years survival rate ( =0.001; HR=9.98, 95% CI=2.64-37.77) for cervical cancer patients. In conclusion, pelvic lymph node status rather than SNPs was the only independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.
ISSN:1449-1907
1449-1907
DOI:10.7150/ijms.40204