Early and Quantitative Assessment of Myocardial Deformation in Essential Hypertension Patients by Using Cardiovascular Magnetic Resonance Feature Tracking

The aims of the study were to identify subclinical global systolic function abnormalities and evaluate influencing factors associated with left ventricular (LV) strain parameters in hypertensive subjects using cardiovascular magnetic resonance imaging feature tracking (CMR-FT). The study enrolled 57...

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Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.3582-3582, Article 3582
Main Authors: Liu, Huina, Wang, Jiajia, Pan, Yukun, Ge, Yinghui, Guo, Zhiping, Zhao, Shihua
Format: Article
Language:English
Subjects:
Adult
Age
Blood Pressure
Essential Hypertension - congenital
Essential Hypertension - diagnosis
Essential Hypertension - diagnostic imaging
Essential Hypertension - physiopathology
Female
Heart
Heart Defects, Congenital - diagnosis
Heart Defects, Congenital - diagnostic imaging
Heart Defects, Congenital - physiopathology
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Hypertension
Magnetic resonance imaging
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Myocardium
Ventricle
Ventricular Function, Left
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Summary:The aims of the study were to identify subclinical global systolic function abnormalities and evaluate influencing factors associated with left ventricular (LV) strain parameters in hypertensive subjects using cardiovascular magnetic resonance imaging feature tracking (CMR-FT). The study enrolled 57 patients with essential hypertension (mean age: 43.04 ± 10.90 years; 35 males) and 26 healthy volunteers (mean age: 38.69 ± 10.44 years; 11 males) who underwent clinical evaluation and CMR examination. Compared with controls, hypertensive patients had significantly impaired myocardial strain values while ejection fraction (EF) did not differ. After multivariate regression analyses adjustment for confounders, the global radial strains (GRS) was independently associated with the mean arterial pressure (MAP) and left ventricular mass index (LVMI) (β = -0.219, p = 0.009 and β = -0.224, p = 0.015, respectively; Adjusted R  = 0.4); the global circumferential strains (GCS) was also independently associated with the MAP and LVMI (β = 0.084, p = 0.002 and β = 0.073, p = 0.01, respectively; Adjusted R = 0.439); the global longitudinal strains (GLS) was independently associated with the Age and MAP (β = 0.065, p = 0.021 and β = 0.077, p = 0.009, respectively; Adjusted R  = 0.289). Myocardial strain can early detect the myocardial damage and may be an appropriate target for preventive strategies before abnormalities of EF.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-60537-x