Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease

Approximately 60% to 80% of people with Parkinson's disease (PD) experience cognitive impairment that impacts on their quality of life. Cognitive decline is a core feature of the disease and can often present before the onset of motor symptoms. Cognitive training may be a useful non-pharmacolog...

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Bibliographic Details
Published in:Cochrane database of systematic reviews 2020-02, Vol.2 (2), p.CD011961
Main Authors: Orgeta, Vasiliki, McDonald, Kathryn R, Poliakoff, Ellen, Hindle, John Vincent, Clare, Linda, Leroi, Iracema
Format: Article
Language:English
Subjects:
Activities of Daily Living
Aged
Aged, 80 and over
Akinetic‐rigid syndrome
Cognitive Dysfunction - rehabilitation
Cognitive Dysfunction - therapy
Dementia - rehabilitation
Dementia - therapy
Humans
Improving cognition
Mental health
Neurology
Parkinson Disease - psychology
Quality of Life
Randomized Controlled Trials as Topic
Task Performance and Analysis
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Summary:Approximately 60% to 80% of people with Parkinson's disease (PD) experience cognitive impairment that impacts on their quality of life. Cognitive decline is a core feature of the disease and can often present before the onset of motor symptoms. Cognitive training may be a useful non-pharmacological intervention that could help to maintain or improve cognition and quality of life for people with PD dementia (PDD) or PD-related mild cognitive impairment (PD-MCI). To determine whether cognitive training (targeting single or multiple domains) improves cognition in people with PDD and PD-MCI or other clearly defined forms of cognitive impairment in people with PD. We searched the Cochrane Dementia and Cognitive Improvement Group Trials Register (8 August 2019), the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, and PsycINFO. We searched reference lists and trial registers, searched relevant reviews in the area and conference proceedings. We also contacted experts for clarifications on data and ongoing trials. We included randomised controlled trials where the participants had PDD or PD-MCI, and where the intervention was intended to train general or specific areas of cognitive function, targeting either a single domain or multiple domains of cognition, and was compared to a control condition. Multicomponent interventions that also included motor or other elements were considered eligible. Two review authors independently screened titles, abstracts, and full-text articles for inclusion in the review. Two review authors also independently undertook extraction of data and assessment of methodological quality. We used GRADE methods to assess the overall quality of the evidence. Seven studies with a total of 225 participants met the inclusion criteria for this review. All seven studies compared the effects of a cognitive training intervention to a control intervention at the end of treatment periods lasting four to eight weeks. Six studies included people with PD living in the community. These six studies recruited people with single-domain (executive) or multiple-domain mild cognitive impairment in PD. Four of these studies identified participants with MCI using established diagnostic criteria, and two included both people with PD-MCI and people with PD who were not cognitively impaired. One study recruited people with a diagnosis of PD dementia who were living in long-term care settings. The cognitive training intervention in th
ISSN:1469-493X
1469-493X
DOI:10.1002/14651858.CD011961.pub2