A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis

The major environmental risk factor for rheumatoid arthritis (RA) is smoking, which according to a widely accepted model induces protein citrullination in the lungs, triggering the production of anti-citrullinated protein antibodies (ACPA) and RA development. Nevertheless, some research findings do...

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Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.3355-3355, Article 3355
Main Authors: Regueiro, Cristina, Rodriguez-Rodriguez, Luis, Lopez-Mejias, Raquel, Nuño, Laura, Triguero-Martinez, Ana, Perez-Pampin, Eva, Corrales, Alfonso, Villalba, Alejandro, Lopez-Golan, Yolanda, Abasolo, Lydia, Remuzgo-Martínez, Sara, Ortiz, Ana M, Herranz, Eva, Martínez-Feito, Ana, Conde, Carmen, Mera-Varela, Antonio, Balsa, Alejandro, Gonzalez-Alvaro, Isidoro, González-Gay, Miguel Ángel, Fernandez-Gutierrez, Benjamín, Gonzalez, Antonio
Format: Article
Language:English
Subjects:
Anti-Citrullinated Protein Antibodies - blood
Anti-Citrullinated Protein Antibodies - immunology
Antibodies
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - immunology
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Citrulline
Epitopes
Epitopes - immunology
Female
HLA-DRB1 Chains - immunology
Humans
Immunoglobulins
Immunologic Tests
Male
Patients
Peptides, Cyclic - immunology
Protein Carbamylation - immunology
Proteins
Rheumatoid arthritis
Rheumatoid factor
Rheumatoid Factor - blood
Rheumatoid Factor - immunology
Risk Factors
Seroepidemiologic Studies
Smoking
Smoking - adverse effects
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Summary:The major environmental risk factor for rheumatoid arthritis (RA) is smoking, which according to a widely accepted model induces protein citrullination in the lungs, triggering the production of anti-citrullinated protein antibodies (ACPA) and RA development. Nevertheless, some research findings do not fit this model. Therefore, we obtained six independent cohorts with 2253 RA patients for a detailed analysis of the association between smoking and RA autoantibodies. Our results showed a predominant association of smoking with the concurrent presence of the three antibodies: rheumatoid factor (RF), ACPA and anti-carbamylated protein antibodies (ACarPA) (3 Ab vs. 0 Ab: OR = 1.99, p = 2.5 × 10 ). Meta-analysis with previous data (4491 patients) confirmed the predominant association with the concurrent presence of the three antibodies (3 Ab vs. 0 Ab: OR = 2.00, p = 4.4 ×10 ) and revealed that smoking was exclusively associated with the presence of RF in patients with one or two antibodies (RF vs. RF : OR = 1.32, p = 0.0002). In contrast, no specific association with ACPA or ACarPA was found. Therefore, these results showed the need to understand how smoking favors the concordance of RA specific antibodies and RF triggering, perhaps involving smoking-induced epitope spreading and other hypothesized mechanisms.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-60305-x