Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial

The purpose of this study is to evaluate the efficiency of local platelet-rich plasma (PRP) injection as an adjuvant treatment after carpal ligament release. We conducted a prospective randomized, triple-blinded, controlled trial. Fifty participants with mild to extreme carpal tunnel syndrome (CTS)...

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Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.2085-2085, Article 2085
Main Authors: Trull-Ahuir, Carmen, Sala, Diego, Chismol-Abad, Joaquín, Vila-Caballer, Marian, Lisón, Juan Francisco
Format: Article
Language:English
Subjects:
Carpal tunnel syndrome
Carpal Tunnel Syndrome - surgery
Carpal Tunnel Syndrome - therapy
Double-Blind Method
Female
Hand Strength
Humans
Ligaments
Ligaments, Articular - surgery
Male
Middle Aged
Patients
Platelet-Rich Plasma - physiology
Platelets
Return to Work
Surgery
Treatment Outcome
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Summary:The purpose of this study is to evaluate the efficiency of local platelet-rich plasma (PRP) injection as an adjuvant treatment after carpal ligament release. We conducted a prospective randomized, triple-blinded, controlled trial. Fifty participants with mild to extreme carpal tunnel syndrome (CTS) were randomly assigned either to the PRP (n = 25) or the platelet-poor plasma (PPP, n = 25) group. After performing open surgical release of the carpal ligament, the inside of the carpal tunnel was irrigated with 3 mL of PRP or PPP according to each participant's group allocation. The primary outcome was hand grip strength (HGS). Secondary outcomes were the time taken off work after surgery (in days) and scores on the Wong-Baker Faces Scale, Boston Carpal Tunnel Questionnaire, and Southampton Wound Assessment Scale. We evaluated patients before treatment and at 6-weeks. As expected, the pain levels, symptom severity, and functional status improved in all the patients after surgery. However, intragroup analysis revealed that only the participants in the PRP group had regained their pre-operative HGS levels at 6-weeks follow-up. These findings indicate that PRP is an effective adjuvant treatment in patients with mild to severe CTS who require surgery.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-59113-0