PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON MYOCARDIUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

To evaluate the protective effect of oil (NSO) on the myocardium in streptozotocin-induced diabetic rats. Thirty-two 7-8-week-old female Wistar albino rats (300-350 g) were equally divided into 4 groups: nondiabetic untreated animals (control), diabetes mellitus (DM), NSO, and DM+NSO groups. For the...

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Published in:Acta endocrinologica (Bucharest, Romania : 2005) Romania : 2005), 2019-07, Vol.15 (3), p.289-294
Main Authors: Altun, E, Avci, E, Yildirim, T, Yildirim, S
Format: Article
Language:English
Subjects:
General Endocrinology
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Summary:To evaluate the protective effect of oil (NSO) on the myocardium in streptozotocin-induced diabetic rats. Thirty-two 7-8-week-old female Wistar albino rats (300-350 g) were equally divided into 4 groups: nondiabetic untreated animals (control), diabetes mellitus (DM), NSO, and DM+NSO groups. For the induction of diabetes, 45 mg/kg streptozotocin was applied to the rats in the DM and DM+NSO groups as a single intraperitoneal dose. NSO (400 mg/kg) was orally administered through an intragastric catheter once a day over 21 days. Formalin-fixed, paraffin-embedded tissue sections of the myocardium were evaluated histopathologically and immunohistochemically. Compared to the control, NSO, and DM+NSO groups, the myocardial tissue samples from the rats in the DM group had significantly higher myositis, hyaline degeneration, and Zenker's necrosis. Moreover, the Bcl-2 expressions were significantly higher in the control, NSO, and DM+NSO groups than in the DM group. NSO has a protective effect on the myocardium of streptozotocin-induced diabetic rats, most likely via suppressing apoptosis.
ISSN:1841-0987
1843-066X
DOI:10.4183/aeb.2019.289