Genome mining for lasso peptides: past, present, and future

Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven approaches, now, the vast majority of lasso peptide discovery is driven by genome-mining approaches. This paper starts with a historical overview...

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Bibliographic Details
Published in:Journal of industrial microbiology & biotechnology 2019-10, Vol.46 (9-10), p.1371-1379
Main Authors: Cheung-Lee, Wai Ling, Link, A. James
Format: Article
Language:English
Subjects:
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Biotechnology
Gene clusters
Genetic Engineering
Genome
Genomes
Humans
Inorganic Chemistry
Life Sciences
Microbiology
Multigene Family
Natural Products - Review
Peptides
Peptides - chemistry
Peptides - genetics
Peptides - metabolism
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Summary:Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven approaches, now, the vast majority of lasso peptide discovery is driven by genome-mining approaches. This paper starts with a historical overview of the first genome-mining approaches for lasso peptide discovery, and then covers new tools that have emerged. Several examples of novel lasso peptides that have been discovered via genome mining are presented as are examples of new enzymes found associated with lasso peptide gene clusters. Finally, this paper concludes with future directions and unsolved challenges in lasso peptide genome mining.
ISSN:1367-5435
1476-5535
DOI:10.1007/s10295-019-02197-z