Optimized depth-resolved estimation to measure optical attenuation coefficients from optical coherence tomography and its application in cerebral damage determination

The optical attenuation coefficient (OAC) reflects the optical properties of various tissues or tissues of the same type under different physiological conditions. Quantitative measurement of OAC from optical coherence tomography (OCT) signals can provide additional information and can increase the p...

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Bibliographic Details
Published in:	Journal of biomedical optics 2019-03, Vol.24 (3), p.1-11
Main Authors:	Liu, Jian, Ding, Ning, Yu, Yao, Yuan, Xincheng, Luo, Shuzhuo, Luan, Jingmin, Zhao, Yuqian, Wang, Yi, Ma, Zhenhe
Format:	Article
Language:	eng
Subjects:	Angiography Attenuation coefficients Brain damage Brain injury Damage detection Ischemia Optical Coherence Tomography Optical communication Optical properties Signal processing Stroke Tomography
Online Access:	Get full text
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Summary:	The optical attenuation coefficient (OAC) reflects the optical properties of various tissues or tissues of the same type under different physiological conditions. Quantitative measurement of OAC from optical coherence tomography (OCT) signals can provide additional information and can increase the potential for OCT applications. We present an optimized depth-resolved estimation (ODRE) method that derives a precise mapping between the measured OCT signal and the OAC. In contrast to previous depth-resolved estimation (DRE) methods, the optimized method can estimate the OAC in any depth range and ignore whether the light is completely attenuated. Numerical simulations and phantom experiments are used to verify its validity, and this method is applied to detect cerebral damage. In combination with OCT angiography, real-time observation of the change of blood perfusion and the degree of cerebral damage in mice with focal cerebral ischemia provides important information to help us understand the temporal relationship between brain damage and ischemia.
ISSN:	1083-3668 1560-2281