Population pharmacokinetics of sildenafil in extremely premature infants

Aims To characterize the population pharmacokinetics (PK) of sildenafil and its active metabolite, N‐desmethyl sildenafil (DMS), in premature infants. Methods We performed a multicentre, open‐label trial to characterize the PK of sildenafil in infants ≤28 weeks gestation and 

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Bibliographic Details
Published in:British journal of clinical pharmacology 2019-12, Vol.85 (12), p.2824-2837
Main Authors: Gonzalez, Daniel, Laughon, Matthew M., Smith, P. Brian, Ge, Shufan, Ambalavanan, Namasivayam, Atz, Andrew, Sokol, Gregory M., Hornik, Chi D., Stewart, Dan, Mundakel, Gratias, Poindexter, Brenda B., Gaedigk, Roger, Mills, Mary, Cohen‐Wolkowiez, Michael, Martz, Karen, Hornik, Christoph P.
Format: Article
Language:English
Subjects:
Administration, Oral
Cohort Studies
Cytochrome P-450 CYP3A - blood
Cytochrome P-450 CYP3A - genetics
Fluconazole - administration & dosage
Fluconazole - pharmacokinetics
Gestational Age
Humans
Hypertension, Pulmonary - blood
Hypertension, Pulmonary - drug therapy
Infant
Infant, Newborn
Infant, Premature - blood
Infant, Premature, Diseases - blood
Infant, Premature, Diseases - drug therapy
Injections, Intravenous
Models, Biological
Original
pharmacokinetics
Phosphodiesterase 5 Inhibitors - administration & dosage
Phosphodiesterase 5 Inhibitors - blood
Phosphodiesterase 5 Inhibitors - pharmacokinetics
Phosphodiesterase 5 Inhibitors - therapeutic use
premature infants
sildenafil
Sildenafil Citrate - administration & dosage
Sildenafil Citrate - blood
Sildenafil Citrate - pharmacokinetics
Sildenafil Citrate - therapeutic use
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Summary:Aims To characterize the population pharmacokinetics (PK) of sildenafil and its active metabolite, N‐desmethyl sildenafil (DMS), in premature infants. Methods We performed a multicentre, open‐label trial to characterize the PK of sildenafil in infants ≤28 weeks gestation and 
ISSN:0306-5251
1365-2125
1365-2125
DOI:10.1111/bcp.14111