Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease

Psoriasis is a common chronic skin disorder characterized by keratinocyte hyperproliferation with altered differentiation accompanied by inflammation and increased angiogenesis. It remains unclear whether the first events that initiate psoriasis development occur in keratinocytes or inflammatory cel...

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Published in:Science advances 2020-01, Vol.6 (2), p.eaax5849-eaax5849
Main Authors: Benhadou, Farida, Glitzner, Elisabeth, Brisebarre, Audrey, Swedlund, Benjamin, Song, Yura, Dubois, Christine, Rozzi, Milena, Paulissen, Catherine, Del Marmol, Veronique, Sibilia, Maria, Blanpain, Cédric
Format: Article
Language:English
Subjects:
Cell Biology
Diseases and Disorders
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Summary:Psoriasis is a common chronic skin disorder characterized by keratinocyte hyperproliferation with altered differentiation accompanied by inflammation and increased angiogenesis. It remains unclear whether the first events that initiate psoriasis development occur in keratinocytes or inflammatory cells. Here, using different psoriasis mouse models, we showed that conditional deletion of or in epidermal cells inhibited psoriasis mediated by overexpression or deletion. Administration of anti-Nrp1 antibody reverted the psoriasis phenotype. Using transcriptional and chromatin profiling of epidermal cells following overexpression together with or deletion, we identified the gene regulatory network regulated by / / during psoriasis development and uncovered a key role of Fosl1 in regulating the chromatin remodeling mediated by overexpression in keratinocytes. In conclusion, our study identifies an epidermal autonomous function of Vegfa/Nrp1/Flt1 that mediates psoriatic-like disease and demonstrates the clinical relevance of blocking Vegfa/Nrp1/Flt1 axis in psoriasis.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.aax5849