Pregnancy complications and cardiovascular disease death: 50-year follow-up of the Child Health and Development Studies pregnancy cohort

Few studies have investigated the combination of pregnancy complications that predict risk for cardiovascular disease (CVD) death and how risk changes with age. This report presents a comprehensive investigation of the relation of the occurrence of multiple pregnancy complications to CVD death over...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2015-09, Vol.132 (13), p.1234-1242
Main Authors: Cirillo, Piera M, Cohn, Barbara A
Format: Article
Language:English
Subjects:
Adult
Anemia - blood
Anemia - epidemiology
California - epidemiology
Cardiovascular Diseases - mortality
Cause of Death
Female
Follow-Up Studies
Forecasting
Glycosuria - epidemiology
Hemoglobins - analysis
Humans
Hypertension - epidemiology
Hypertension, Pregnancy-Induced - epidemiology
Infant, Newborn
Infant, Premature
Infant, Small for Gestational Age
Obstetric Labor, Premature - epidemiology
Pre-Eclampsia - epidemiology
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - epidemiology
Prognosis
Proportional Hazards Models
Risk Factors
Young Adult
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Summary:Few studies have investigated the combination of pregnancy complications that predict risk for cardiovascular disease (CVD) death and how risk changes with age. This report presents a comprehensive investigation of the relation of the occurrence of multiple pregnancy complications to CVD death over 5 decades in a large pregnancy cohort. We examined pregnancy events (1959-1967) and CVD death through 2011 in 14 062 women from the Child Health and Development Studies. CVD death was determined by linkage to California Vital Statistics and National Death Index. Women were a median age of 26 years at enrollment and 66 years in 2011. Preexisting hypertension (hazard ratio, 3.5; 95% confidence interval, 2.4-5.1); glycosuria (hazard ratio, 4.2; confidence interval, 1.3-13.1); late-onset preeclampsia (after week 34, hazard ratio, 2.0; confidence interval, 1.2-3.5); and hemoglobin decline over the second and third trimesters (hazard ratio, 1.7; confidence interval, 1.2-2.7) predicted CVD death. Delivery of a small-for-gestation or preterm infant and early-onset preeclampsia (by week 34) significantly predicted premature CVD death (P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.113.003901