Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast - Magnetic Resonance Fingerprinting

Synchronous assessment of multiple MRI contrast agents in a single scanning session would provide a new "multi-color" imaging capability similar to fluorescence imaging but with high spatiotemporal resolution and unlimited imaging depth. This multi-agent MRI technology would enable a whole...

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Bibliographic Details
Published in:Scientific reports 2019-12, Vol.9 (1), p.19888-11, Article 19888
Main Authors: Anderson, Christian E, Johansen, Mette, Erokwu, Bernadette O, Hu, He, Gu, Yuning, Zhang, Yifan, Kavran, Michael, Vincent, Jason, Drumm, Mitchell L, Griswold, Mark A, Steinmetz, Nicole F, Li, Ming, Clark, Heather, Darrah, Rebecca J, Yu, Xin, Brady-Kalnay, Susann M, Flask, Chris A
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Contrast agents
Contrast Media - chemistry
Contrast Media - pharmacology
Female
Fingerprinting
Gadolinium
Gadolinium - chemistry
Gadolinium - pharmacology
Glioma
Glioma - diagnostic imaging
Humans
Magnetic Resonance Imaging
Mapping
Mass spectroscopy
Meglumine - analogs & derivatives
Meglumine - chemistry
Meglumine - pharmacology
Mice
Mice, Nude
Neoplasms, Experimental - diagnostic imaging
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Spatial discrimination
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Summary:Synchronous assessment of multiple MRI contrast agents in a single scanning session would provide a new "multi-color" imaging capability similar to fluorescence imaging but with high spatiotemporal resolution and unlimited imaging depth. This multi-agent MRI technology would enable a whole new class of basic science and clinical MRI experiments that simultaneously explore multiple physiologic/molecular events in vivo. Unfortunately, conventional MRI acquisition techniques are only capable of detecting and quantifying one paramagnetic MRI contrast agent at a time. Herein, the Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF) methodology was extended for in vivo application and evaluated by simultaneously and dynamically mapping the intra-tumoral concentration of two MRI contrast agents (Gd-BOPTA and Dy-DOTA-azide) in a mouse glioma model. Co-registered gadolinium and dysprosium concentration maps were generated with sub-millimeter spatial resolution and acquired dynamically with just over 2-minute temporal resolution. Mean tumor Gd and Dy concentration measurements from both single agent and dual agent DC-MRF studies demonstrated significant correlations with ex vivo mass spectrometry elemental analyses. This initial in vivo study demonstrates the potential for DC-MRF to provide a useful dual-agent MRI platform.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-56531-7