Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria

Chronic graft-versus-host disease (cGVHD) and late acute graft-versus-host disease (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes of Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accurac...

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Published in:Blood 2019-07, Vol.134 (3), p.304-316
Main Authors: Cuvelier, Geoffrey D.E., Nemecek, Eneida R., Wahlstrom, Justin T., Kitko, Carrie L., Lewis, Victor A., Schechter, Tal, Jacobsohn, David A., Harris, Andrew C., Pulsipher, Michael A., Bittencourt, Henrique, Choi, Sung Won, Caywood, Emi H., Kasow, Kimberly A., Bhatia, Monica, Oshrine, Benjamin R., Flower, Allyson, Chaudhury, Sonali, Coulter, Donald, Chewning, Joseph H., Joyce, Michael, Savaşan, Süreyya, Pawlowska, Anna B., Megason, Gail C., Mitchell, David, Cheerva, Alexandra C., Lawitschka, Anita, West, Lori J., Pan, Bo, Al Hamarneh, Yazid N., Halevy, Anat, Schultz, Kirk R.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Age Factors
Child
Child, Preschool
Chronic Disease
CME
Consensus Development Conferences, NIH as Topic
Female
Graft vs Host Disease - diagnosis
Graft vs Host Disease - etiology
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Male
Practice Guidelines as Topic
Risk Factors
Severity of Illness Index
Symptom Assessment
Time Factors
Transplantation
Transplantation, Homologous
United States
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Summary:Chronic graft-versus-host disease (cGVHD) and late acute graft-versus-host disease (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes of Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy of cGVHD and to better classify graft-versus-host disease (GVHD) syndromes but have not been validated in patients
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2019000216