Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

A copper‐catalyzed silylation of propargyl dichlorides was developed to access chloro‐substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro‐substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol....

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-11, Vol.58 (46), p.16538-16542
Main Authors: Liu, Zheng‐Li, Yang, Chao, Xue, Qi‐Yan, Zhao, Meng, Shan, Cui‐Cui, Xu, Yun‐He, Loh, Teck‐Peng
Format: Article
Language:English
Subjects:
allenes
Communication
Communications
Copper
Dichlorides
enantioselectivity
silanes
Substitutes
synthetic methods
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Summary:A copper‐catalyzed silylation of propargyl dichlorides was developed to access chloro‐substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro‐substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol. A copper‐catalyzed silylation reaction of propargyl dichlorides has been developed. In this protocol, racemic and enantioenriched chloro‐substituted allenylsilanes can be accessed with high efficiency under mild reaction conditions. The corresponding products were transformed into a variety of useful synthons.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201908343