Empirical‐likelihood‐based criteria for model selection on marginal analysis of longitudinal data with dropout missingness

Longitudinal data are common in clinical trials and observational studies, where missing outcomes due to dropouts are always encountered. Under such context with the assumption of missing at random, the weighted generalized estimating equation (WGEE) approach is widely adopted for marginal analysis....

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Bibliographic Details
Published in:	Biometrics 2019-09, Vol.75 (3), p.950-965
Main Authors:	Chen, Chixiang, Shen, Biyi, Zhang, Lijun, Xue, Yuan, Wang, Ming
Format:	Article
Language:	eng
Subjects:	Akaike information criterion Bayesian analysis Bayesian information criterion Clinical trials Computer Simulation Correlation analysis Criteria Data analysis Data Interpretation, Statistical Embedding Empirical analysis empirical likelihood Humans Likelihood Functions Longitude longitudinal data Longitudinal Studies Marginal analysis missing at random model selection Models, Statistical Patient Dropouts Regression analysis weighted generalized estimating equation
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Summary:	Longitudinal data are common in clinical trials and observational studies, where missing outcomes due to dropouts are always encountered. Under such context with the assumption of missing at random, the weighted generalized estimating equation (WGEE) approach is widely adopted for marginal analysis. Model selection on marginal mean regression is a crucial aspect of data analysis, and identifying an appropriate correlation structure for model fitting may also be of interest and importance. However, the existing information criteria for model selection in WGEE have limitations, such as separate criteria for the selection of marginal mean and correlation structures, unsatisfactory selection performance in small‐sample setups, and so forth. In particular, there are few studies to develop joint information criteria for selection of both marginal mean and correlation structures. In this work, by embedding empirical likelihood into the WGEE framework, we propose two innovative information criteria named a joint empirical Akaike information criterion and a joint empirical Bayesian information criterion, which can simultaneously select the variables for marginal mean regression and also correlation structure. Through extensive simulation studies, these empirical‐likelihood‐based criteria exhibit robustness, flexibility, and outperformance compared to the other criteria including the weighted quasi‐likelihood under the independence model criterion, the missing longitudinal information criterion, and the joint longitudinal information criterion. In addition, we provide a theoretical justification of our proposed criteria, and present two real data examples in practice for further illustration.
ISSN:	0006-341X 1541-0420