Alleviating Effect of α-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats

Cadmium exposure contributes to internal organ dysfunction and the development of chronic diseases. The aim of the study was to assess the alleviating effect of α-lipoic acid and/or magnesium on cadmium-induced oxidative stress and disorders in bone metabolism, kidney and liver function, and hematol...

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Bibliographic Details
Published in:International journal of environmental research and public health 2019-11, Vol.16 (22), p.4483
Main Authors: Markiewicz-Górka, Iwona, Pawlas, Krystyna, Jaremków, Aleksandra, Januszewska, Lidia, Pawłowski, Paweł, Pawlas, Natalia
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Anticoagulants
Antioxidants
Antioxidants - pharmacology
Apoptosis
Ascorbic acid
Batteries
Body weight
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone turnover
Bones
Cadmium
Cadmium - toxicity
Chelation
Chronic illnesses
Consumption
Corrosion prevention
Depletion
Diet
Dietary supplements
Enzymatic activity
Experiments
Flavonoids
Hematology
Inflammation
Kidney - drug effects
Kidney - metabolism
Kidneys
Laboratories
Lipid peroxidation
Lipids
Lipoic acid
Liver - drug effects
Liver - metabolism
Magnesium
Magnesium - pharmacology
Male
Medical research
Metabolism
Metals
Neurotoxicity
Nickel cadmium batteries
Occupational exposure
Oxidative metabolism
Oxidative stress
Oxidative Stress - drug effects
Peroxidation
Peroxides
Pesticides
Photovoltaic cells
Photovoltaics
Pigments
Polymers
Polyphenols
Rats, Wistar
Smelters
Solar energy
Solar panels
Strawberries
Thioctic Acid - pharmacology
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vitamin E
Welding machines
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Summary:Cadmium exposure contributes to internal organ dysfunction and the development of chronic diseases. The aim of the study was to assess the alleviating effect of α-lipoic acid and/or magnesium on cadmium-induced oxidative stress and disorders in bone metabolism, kidney and liver function, and hematological and biochemical parameters changes. Male rats were exposed to cadmium (30 mg Cd/kg of feed) for three months. Some animals exposed to Cd were supplemented with magnesium (150 mg Mg/kg of feed) and/or with α-lipoic acid (100 mg/kg body weight, four times a week). Cd intake inhibited body weight gain and lowered hemoglobin concentration, whereas it increased the activities of liver enzymes, as well as the level of oxidative stress, CTX-1 (C-terminal telopeptide of type I collagen, bone resorption marker), and CRP (C-reactive protein, marker of inflammation); it decreased vitamin D3, GSH (reduced glutathione), and the serum urea nitrogen/creatinine index. Mg and/or α-lipoic acid supplementation increased the antioxidant potential, and partially normalized the studied biochemical parameters. The obtained results show that both magnesium and α-lipoic acid decrease oxidative stress and the level of inflammatory marker, as well as normalize bone metabolism and liver and kidney function. Combined intake of α-lipoic acid and magnesium results in reinforcement of the protective effect; especially, it increases antioxidant defense.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph16224483