Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus

The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their su...

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Published in:International journal of molecular sciences 2019-11, Vol.20 (22), p.5679
Main Authors: Navarro Quiroz, Elkin, Chavez-Estrada, Valeria, Macias-Ochoa, Karime, Ayala-Navarro, María Fernanda, Flores-Aguilar, Aniyensy Sarai, Morales-Navarrete, Francisco, de la Cruz Lopez, Fernando, Gomez Escorcia, Lorena, Musso, Carlos G, Aroca Martinez, Gustavo, Gonzales Torres, Henry, Diaz Perez, Anderson, Cadena Bonfanti, Andres, Sarmiento Gutierrez, Joany, Meza, Jainy, Diaz Arroyo, Esperanza, Bello Lemus, Yesit, Ahmad, Mostapha, Navarro Quiroz, Roberto
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Acetylation
Animals
Apoptosis
CD28 antigen
Chronic conditions
Cytokines
DNA methylation
Epigenesis, Genetic
Epigenetics
Genomes
Glycine
Glycosylation
Histone H4
Humans
Hydroxylation
Interleukin 10
Kinases
Lipopolysaccharides
Lupus
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - metabolism
Lymphocytes T
Lysine
Macrophages
Monocytes
Phagocytes
Phosphorylation
Protein Processing, Post-Translational
Review
Substrates
Systemic lupus erythematosus
Tumor necrosis factor-α
Ubiquitin
Ubiquitin-protein ligase
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Summary:The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the differential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20225679