Guidelines for evaluating myocardial cell death

Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area of myocardial cell death and increasing concerns...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2019-11, Vol.317 (5), p.H891-H922
Main Authors: Mishra, Paras K, Adameova, Adriana, Hill, Joseph A, Baines, Christopher P, Kang, Peter M, Downey, James M, Narula, Jagat, Takahashi, Masafumi, Abbate, Antonio, Piristine, Hande C, Kar, Sumit, Su, Shi, Higa, Jason K, Kawasaki, Nicholas K, Matsui, Takashi
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biomarkers - metabolism
Biomedical Research - standards
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cell Death
Congestive heart failure
Evaluation
Ferroptosis
Guidelines as Topic - standards
Heart
Humans
Identification methods
Intracellular Signaling Peptides and Proteins - metabolism
Measurement methods
Mitochondria
Mortality
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Necroptosis
Necrosis
Pyroptosis
Reproducibility of Results
Review
Signal Transduction
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Summary:Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area of myocardial cell death and increasing concerns over rigor and reproducibility, it is important and timely to set a guideline for the best practices of evaluating myocardial cell death. There are six major forms of regulated cell death observed in cardiac pathologies, namely apoptosis, necroptosis, mitochondrial-mediated necrosis, pyroptosis, ferroptosis, and autophagic cell death. In this article, we describe the best methods to identify, measure, and evaluate these modes of myocardial cell death. In addition, we discuss the limitations of currently practiced myocardial cell death mechanisms.
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00259.2019